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Guan Chen Selected Research

Non-Receptor Type 3 Protein Tyrosine Phosphatase

5/2015Tyrosine dephosphorylation enhances the therapeutic target activity of epidermal growth factor receptor (EGFR) by disrupting its interaction with estrogen receptor (ER).
1/2014Protein-tyrosine phosphatase H1 increases breast cancer sensitivity to antiestrogens by dephosphorylating estrogen receptor at Tyr537.

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Guan Chen Research Topics

Disease

12Neoplasms (Cancer)
07/2018 - 05/2004
9Breast Neoplasms (Breast Cancer)
05/2015 - 07/2002
5Colonic Neoplasms (Colon Cancer)
06/2014 - 05/2004
4Carcinogenesis
01/2022 - 07/2012
2Inflammation (Inflammations)
01/2022 - 03/2021
2Chronic Renal Insufficiency
07/2021 - 03/2021
1Chronic Kidney Disease-Mineral and Bone Disorder (Renal Rickets)
07/2021
1Pain (Aches)
07/2021

Drug/Important Bio-Agent (IBA)

5Mitogen-Activated Protein KinasesIBA
01/2022 - 08/2006
5Proteins (Proteins, Gene)FDA Link
01/2022 - 06/2005
4Phosphoric Monoester Hydrolases (Phosphatases)IBA
07/2018 - 04/2010
4Estrogen ReceptorsIBA
01/2014 - 02/2004
3Phosphotransferases (Kinase)IBA
01/2022 - 05/2004
3p38 Mitogen-Activated Protein KinasesIBA
01/2022 - 05/2004
3Protein Isoforms (Isoforms)IBA
01/2022 - 02/2003
2Non-Receptor Type 3 Protein Tyrosine PhosphataseIBA
05/2015 - 01/2014
2Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
07/2012 - 02/2003
2Protein Kinases (Protein Kinase)IBA
07/2012 - 07/2002
2Estrogens (Estrogen)FDA Link
04/2012 - 08/2006
2arseniteIBA
05/2004 - 02/2003
2Calcitriol Receptors (Calcitriol Receptor)IBA
05/2004 - 07/2002
1MineralsIBA
07/2021
1TabletsIBA
07/2021
1Pharmaceutical PreparationsIBA
03/2021
1AcidsIBA
03/2021
1Therapeutic UsesIBA
03/2021
1Cisplatin (Platino)FDA LinkGeneric
03/2021
1Glucose Transporter Type 2IBA
01/2020
1ErbB Receptors (EGF Receptor)IBA
01/2017
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
05/2015
1Tyrosine Kinase InhibitorsIBA
05/2015
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
05/2015
1Heat-Shock Proteins (Heat-Shock Protein)IBA
06/2014
1TamoxifenFDA LinkGeneric
01/2014
1Tyrosine (L-Tyrosine)FDA Link
01/2014
1Fulvestrant (Faslodex)FDA Link
01/2014
1Estrogen Receptor Modulators (Antiestrogen)IBA
01/2014
1ras ProteinsIBA
08/2012
1Reactive Oxygen Species (Oxygen Radicals)IBA
07/2012
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
07/2012
1AntioxidantsIBA
07/2012
1Hormones (Hormone)IBA
04/2012
1PoisonsIBA
10/2011
1Paclitaxel (Taxol)FDA LinkGeneric
10/2011
1trioctyl phosphine oxide (TOPO)IBA
10/2011
1Type II DNA Topoisomerases (Topoisomerase II)IBA
10/2011
1Chemokine ReceptorsIBA
04/2006
1Transcription Factor AP-1 (Transcription Factor AP 1)IBA
02/2004
1Mitogen-Activated Protein Kinase 13IBA
02/2003
1VitaminsIBA
07/2002
1SteroidsIBA
07/2002

Therapy/Procedure

6Therapeutics
07/2018 - 05/2004
2Surgical Instruments (Clip)
08/2008 - 06/2005
1Nephrectomy
07/2021
1Lymph Node Excision (Lymph Node Dissection)
06/2005